A person is having HBsAg negative, Anti-HBs positive, Anti HBc positive. Most probable diagnosis is?
**Core Concept**
The person in question has a combination of hepatitis B surface antigen (HBsAg) negativity, presence of hepatitis B surface antibody (Anti-HBs), and hepatitis B core antibody (Anti-HBc) positivity. This serological profile is indicative of a specific immune response to hepatitis B virus (HBV) infection.
**Why the Correct Answer is Right**
The presence of Anti-HBs indicates that the person has been either vaccinated against HBV or has recovered from an HBV infection. The presence of Anti-HBc, however, suggests that the person has been exposed to HBV and has mounted an immune response against the core antigen. Given that HBsAg is negative, it suggests that the person is not currently infected with HBV. This profile is most consistent with a person who has recovered from an HBV infection, which is known as the "resolved" or "immune" phase of the infection. The immune system has cleared the virus, and the person has developed long-term immunity against HBV.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided, but typically, other options might include HBV vaccination status, acute/chronic infection, or other interpretations of the serological markers.
* **Option B:** This option might imply a false-positive result for Anti-HBc, which is unlikely and not supported by the clinical context.
* **Option C:** This option might suggest a false-negative result for HBsAg, which is also unlikely given the presence of Anti-HBs.
* **Option D:** This option might imply a chronic HBV infection, which is not supported by the absence of HBsAg and the presence of Anti-HBs.
**Clinical Pearl / High-Yield Fact**
In cases of HBV infection, the presence of Anti-HBc without HBsAg positivity suggests that the person has either recovered from an acute infection or is in the immune phase of the disease. This serological profile has significant implications for public health, as it indicates that the person is not infectious but still has long-term immunity against HBV.
**Correct Answer: C. Resolved HBV infection.**