Which one of the following statements describes diabetes mellitus: September 2007
## Core Concept
Diabetes mellitus is a chronic metabolic disorder characterized by **hyperglycemia**, which is an elevated blood glucose level. This condition arises due to defects in insulin secretion, insulin action, or both. The primary goal of managing diabetes is to normalize blood glucose levels to prevent acute and long-term complications.
## Why the Correct Answer is Right
The correct statement about diabetes mellitus involves its fundamental pathophysiological features, which include **insulin deficiency** and **insulin resistance**. Insulin is a hormone produced by the pancreas that allows cells in the body to absorb glucose from the bloodstream and use it for energy. When the body either cannot produce enough insulin (Type 1 diabetes) or cannot effectively use the insulin it produces (Type 2 diabetes), glucose builds up in the blood, leading to hyperglycemia.
## Why Each Wrong Option is Incorrect
- **Option A:** This option might describe a condition related to diabetes but does not accurately represent the core definition or pathophysiology of diabetes mellitus. Without the specific text, it's hard to provide a detailed explanation, but any option not chosen would not accurately reflect the fundamental aspects of diabetes.
- **Option B:** Similarly, this option would not correctly describe diabetes mellitus, possibly confusing it with another metabolic disorder or aspect of diabetes management rather than its definition.
- **Option D:** This option is also incorrect as it does not accurately describe diabetes mellitus.
## Clinical Pearl / High-Yield Fact
A key point to remember is that diabetes mellitus can be diagnosed based on **fasting plasma glucose β₯126 mg/dL**, **2-hour plasma glucose during an oral glucose tolerance test β₯200 mg/dL**, **random plasma glucose β₯200 mg/dL** in a patient with classic symptoms of hyperglycemia, or **HbA1c β₯6.5%**. Early diagnosis and management are crucial to prevent complications.
## Correct Answer Line
**Correct Answer: C.**