**Question:** Which of the following Antihypertensive is preferred in cases of comorbid Diabetes Mellitus

**Core Concept:** Choosing the appropriate antihypertensive medication in patients with diabetes mellitus is crucial to minimize the risk of cardiovascular events and kidney damage.

**Why the Correct Answer is Right:** In patients with diabetes mellitus, the selection of antihypertensive medication should focus on reducing cardiovascular risk and preserving kidney function. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are preferred choices due to their renoprotective effect, reducing the risk of cardiovascular events, and maintaining glycemic control.

**Why Each Wrong Option is Incorrect:**

A. Calcium channel blockers (CCBs) are less effective in reducing cardiovascular events compared to ACEIs and ARBs.

B. Beta-blockers are less effective in reducing cardiovascular events and have a higher risk of worsening glycemic control.

C. Diuretics are effective in reducing blood pressure but are not as renoprotective as ACEIs, ARBs, and angiotensin receptor mineralocorticoid antagonists (ARMA).

D. Alpha-blockers are not as effective as ACEIs, ARBs, and ARMA in reducing cardiovascular events and preserving kidney function.

**Clinical Pearl / High-Yield Fact:** ACEIs, ARBs, and ARMA have a superior renoprotective effect compared to other antihypertensive classes, making them the preferred choice in patients with diabetes mellitus. Diabetes mellitus increases the risk of cardiovascular complications, and using these medications reduces this risk while maintaining glycemic control.