Addition of which of the following agent can help in elimination of 15-20 tablets of 10 mg dextroamphetamine –
**Core Concept**
The question is testing the student's knowledge of the pharmacological management of amphetamine overdose, specifically the use of a medication to aid in the elimination of the drug from the body. Amphetamine is a central nervous system stimulant that can cause severe cardiovascular and psychiatric symptoms in overdose.
**Why the Correct Answer is Right**
The correct answer is **Activated Charcoal**. Activated charcoal is a highly adsorbent material that can bind to amphetamine in the gastrointestinal tract, preventing its absorption into the bloodstream. This can help reduce the peak concentration of amphetamine and its elimination half-life, thereby facilitating its elimination from the body. Activated charcoal is often used in the management of overdose with various medications, including amphetamines.
**Why Each Wrong Option is Incorrect**
* **Option A:** Naloxone is an opioid antagonist that is used to reverse opioid overdose, not amphetamine overdose. It is not effective in eliminating amphetamine from the body.
* **Option B:** Physostigmine is a cholinesterase inhibitor that can be used to reverse anticholinergic toxicity, but it is not used to eliminate amphetamine from the body.
* **Option D:** Alprazolam is a benzodiazepine that can be used to treat anxiety and insomnia, but it is not effective in eliminating amphetamine from the body.
**Clinical Pearl / High-Yield Fact**
Activated charcoal is most effective in eliminating drugs from the body when administered within 1 hour of ingestion. However, it is essential to note that activated charcoal should not be used in patients with impaired gag reflex, gastrointestinal obstruction, or those who are unconscious.
**Correct Answer:** A. Activated Charcoal