Dextran is a good plasma expanders, but it has disadvantage of:
**Core Concept**
Dextran is a type of colloid solution used as a plasma expander in the treatment of hypovolemic shock. It works by increasing the blood volume and improving blood pressure. Dextran is a complex carbohydrate that is broken down into smaller molecules in the body, which can lead to various side effects.
**Why the Correct Answer is Right**
Dextran has a disadvantage of causing anaphylactoid reactions, which can manifest as hypotension, tachycardia, and bronchospasm. This is due to the release of histamine from mast cells, which is triggered by the breakdown products of dextran. The mechanism is similar to that of anaphylaxis, but it is not an allergic reaction in the classical sense. The use of dextran can also lead to other complications, such as bleeding and thrombocytopenia, due to its anticoagulant properties.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the primary concern with dextran is not its short duration of action, but rather its potential to cause anaphylactoid reactions and bleeding complications.
**Option B:** This option is incorrect because dextran is not known to cause significant electrolyte imbalances, which is a common concern with other types of plasma expanders.
**Option C:** This option is incorrect because dextran is not typically associated with a high risk of renal toxicity, which is a concern with certain other types of plasma expanders.
**Clinical Pearl / High-Yield Fact**
Dextran should be used with caution in patients with a history of allergies or asthma, as they may be at increased risk of anaphylactoid reactions. It is also essential to monitor patients closely for signs of bleeding or thrombocytopenia when using dextran.
**Correct Answer:** C.