**Question:** Order of development of secondary sexual characteristics in male: September 2012

**Core Concept:** Secondary sexual characteristics refer to the additional physical traits that develop in both males and females after puberty, marking the onset of puberty. These traits are an essential part of the maturation process and are triggered by the release of hormones from the hypothalamus and pituitary gland, which in turn stimulate the gonads (testes in males) to produce sex hormones (testosterone in males).

**Why the Correct Answer is Right:**

Correct Answer: D. pubarche, genital development, facial hair, voice deepening

In males, secondary sexual characteristics start with pubarche, which is the development of body hair, including facial hair. This is followed by the growth of testes, also known as genital development. As testosterone levels continue to rise, the male pubertal process progresses to voice deepening due to the larynx and vocal cords becoming larger, and ultimately, the development of erector pili muscles in the skin, leading to the growth of body hair.

**Why Each Wrong Option is Incorrect:**

A. Facial hair development: While facial hair does develop during puberty, it occurs earlier in the process than the correct answer D (pubarche).
B. Voice deepening: Voice deepening is a later stage in the process than the given correct answer D (pubarche).
C. Erectile response: This refers to the ability to achieve an erection, which is a physiological response, not a distinct stage in the development of secondary sexual characteristics.

**Clinical Pearl:** The understanding of the sequential development of secondary sexual characteristics is crucial for evaluating the maturity and progression of puberty in patients. It can help clinicians diagnose and treat issues related to delayed or advanced puberty, ensuring proper development and hormone therapy when necessary.

Remember to consult a medical professional for clinical advice regarding puberty-related concerns.