An Rh-ve woman became pregnant with Rh+ve fetus.Within few days after bih, the infant developedjaundice, ascites, hepatomegaly and edema. Thelikely substance (s) deposited in skin and sclera injaundice is/are given below. Which is the bestpossible answer

**Core Concept**
The underlying principle being tested is the pathophysiology of hemolytic disease of the newborn (HDN), specifically the effects of Rh incompatibility between an Rh-negative mother and an Rh-positive fetus. This incompatibility leads to the production of anti-Rh antibodies by the mother, which can cross the placenta and cause hemolysis of the fetus's red blood cells.

**Why the Correct Answer is Right**
The correct answer is related to the breakdown products of hemolysis. When red blood cells are lysed, they release their contents, including bilirubin, which is then processed by the liver and excreted into the bile. However, in the context of HDN, the liver of the newborn may not be mature enough to conjugate and excrete bilirubin efficiently, leading to its accumulation in the blood and deposition in tissues, causing jaundice.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not directly relate to the breakdown products of red blood cell hemolysis.
**Option B:** Similarly, this option is incorrect as it is not a direct consequence of the hemolytic process described.
**Option C:** This option is also incorrect for the same reason, lacking a direct connection to the hemolysis and subsequent jaundice.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that the jaundice in hemolytic disease of the newborn is due to the elevated levels of unconjugated (indirect) bilirubin, which can cause significant morbidity if not treated promptly.

**Correct Answer:** D. Bilirubin.

✓ Correct Answer: B. Conjugated and unconjugated bilirubin