**Core Concept**
In the context of managing chronic alcoholism, detoxification involves the process of safely eliminating alcohol and its metabolites from the body. This process requires the use of specific medications to alleviate withdrawal symptoms and reduce the risk of seizures and other complications.

**Why the Correct Answer is Right**
The drug used for detoxification of alcohol in chronic alcoholics is **Flumazenil** is incorrect because it is actually used to reverse benzodiazepine overdose. The correct answer is Disulfiram, which works by inhibiting aldehyde dehydrogenase, an enzyme involved in the metabolism of acetaldehyde, a toxic byproduct of alcohol metabolism. By blocking this enzyme, Disulfiram forces the body to retain acetaldehyde, which leads to unpleasant symptoms when alcohol is consumed, thereby discouraging drinking.

**Why Each Wrong Option is Incorrect**
**Option A:** Flumazenil is incorrect because it is used to reverse benzodiazepine overdose, not alcohol detoxification.
**Option B:** Naltrexone is incorrect because it is used to manage opioid addiction and alcohol dependence by blocking opioid receptors, but it does not play a direct role in the detoxification process.
**Option C:** Acamprosate is incorrect because it is used to manage alcohol dependence by stabilizing glutamate and GABA neurotransmission, but it does not aid in detoxification.

**Clinical Pearl / High-Yield Fact**
Disulfiram is a classic example of a pharmacological agent that uses a "chemical aversion" approach to discourage drinking by inducing unpleasant symptoms when alcohol is consumed.

**Correct Answer:** D. Disulfiram.