Despite their sho half lives(2hrs) proton pump inhibitors cause a prolonged suppresion of acid secretiin(upto 48hr) because:
Correct Answer: They irreversibly inhibit the proton pump molecule and hence,acid secretion requires synthesis of new proton pumps
Description: They irreversibly inhibit the proton pump molecule and hence,acid secretion requires synthesis of new proton pumps(ref Rang and Dale 5/e p370-371, goidman gilman 12/e p1311-1312) The activated form of PPI binds covalently with sulfahydryl groups of cysteine in the H+ K+ atpase ,irreversbly inacativating the pump molecule.acid secretion resumes only after new pump molecules are synthesized and inseed into the luminal membranes ptoviding a prolonged suppresion of acid secretion despite the much shoer pladma half lives of the parent compounds.
Category:
Pharmacology
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