Pharmacology Despite their sho half-lives (2 hrs), proton pump inhibitors (PPIs) cause a prolonged Suppression of acid secretion (up to 48 h) because: A They are prodrugs and undergo activation gradually B They exit from the plasma and enter acid secretory canaliculi and stay there, blocking the secretion of acid for a long time C They irreversibly inhibit the proton pump molecule and hence, acid secretion requires synthesis of new proton pumps D They irreversibly inhibit the proton pump molecule and hence, acid secretion requires synthesis of new proton pumps 💡 Explanation Despite their sho half-lives (2 hrs), proton pump inhibitors (PPIs) cause a prolonged Suppression of acid secretion (up to 48 h) because: ✓ Correct Answer: C. They irreversibly inhibit the proton pump molecule and hence, acid secretion requires synthesis of new proton pumps