**Question:** In Wilson's disease copper deposition occurs in

**Core Concept:** Wilson's disease is a genetic disorder that results from the accumulation of copper in the body, particularly in the central nervous system and liver. The disease is due to mutations in the ATP7B gene, which is responsible for encoding a protein called copper transporter protein (ATP7B) that plays a crucial role in the excretion of copper from the body.

**Why the Correct Answer is Right:** In Wilson's disease, the copper transporter protein (ATP7B) malfunctions, leading to impaired copper excretion and its accumulation in specific organs. The copper accumulates primarily in the liver, causing liver damage and dysfunction. Additionally, copper accumulates in the brain, leading to neurological symptoms.

**Why Each Wrong Option is Incorrect:**

A. Liver: While liver involvement is present in Wilson's disease, it is not the sole site of copper deposition. Copper accumulates in other organs as well.
B. Kidney: Although copper may be present in the kidney, it is not the primary site of copper deposition in Wilson's disease.
C. Brain: Liver involvement is not specific to Wilson's disease; copper accumulation in the brain is seen in this disease, but other neurological disorders also involve brain copper accumulation.
D. None of the above: This is incorrect because the correct answer is that Wilson's disease involves copper deposition in the liver and brain.

**Clinical Pearl:** Wilson's disease is a crucial differential diagnosis to consider in patients presenting with neurological symptoms and liver dysfunction. Early diagnosis and treatment are essential to prevent progressive neurological damage and liver failure.

**Correct Answer:** D. Liver and Brain