**Core Concept**
The management of alcohol dependence involves pharmacological interventions to prevent relapse. This question is testing the knowledge of medications used in the treatment of alcohol use disorder (AUD).

**Why the Correct Answer is Right**
Disulfiram (brand name Antabuse) is an enzyme inhibitor that blocks the metabolism of alcohol by acetaldehyde dehydrogenase, leading to an accumulation of acetaldehyde, a toxic byproduct of alcohol metabolism. This results in an unpleasant reaction when alcohol is consumed, serving as a deterrent to relapse. The correct answer is Disulfiram (Antabuse).

**Why Each Wrong Option is Incorrect**
**Option A:** Naltrexone is an opioid receptor antagonist used to treat opioid dependence and alcohol dependence, but it is not primarily used to prevent relapse by causing an unpleasant reaction when alcohol is consumed.

**Option B:** Acamprosate is used to reduce cravings and prevent relapse in alcohol-dependent individuals, but it does not cause an unpleasant reaction when alcohol is consumed.

**Option C:** Bupropion is an antidepressant that may be used to treat co-occurring depression and alcohol dependence, but it is not primarily used to prevent relapse in alcohol-dependent individuals.

**Clinical Pearl / High-Yield Fact**
Acamprosate is often used in combination with counseling and support groups to help maintain abstinence in individuals with a history of alcohol dependence.

**Correct Answer:** A. Disulfiram (Antabuse).