## Core Concept
The question tests the understanding of DNA synthesis and the enzymes involved in this process. DNA synthesis is a crucial aspect of molecular biology, where deoxyribonucleotides are polymerized into DNA. The enzyme responsible for this process is a key component of DNA replication and repair.

## Why the Correct Answer is Right
The correct answer, **DNA Polymerase**, is the enzyme that catalyzes the polymerization of deoxyribonucleotides into DNA. This enzyme reads template DNA strands and matches the incoming nucleotides to the base pairing rules (adenine with thymine, and cytosine with guanine). DNA polymerase then links these nucleotides together, forming a new DNA strand. This process is essential for DNA replication and repair.

## Why Each Wrong Option is Incorrect
- **Option A:** Helicase is an enzyme involved in unwinding double-stranded DNA into single strands during replication, but it does not polymerize nucleotides into DNA.
- **Option B:** Ligase is an enzyme that seals gaps in DNA by forming a phosphodiester bond between a 5' phosphate and a 3' hydroxyl group, but it does not polymerize deoxyribonucleotides into DNA.
- **Option D:** Topoisomerase is an enzyme that relaxes supercoiled DNA during replication and transcription, but it is not involved in the polymerization of deoxyribonucleotides into DNA.

## Clinical Pearl / High-Yield Fact
A key point to remember is that DNA polymerase requires a primer with a free 3'-hydroxyl group to initiate DNA synthesis. This is a critical aspect of DNA replication and is often a target for antiviral and anticancer therapies.

## Correct Answer: C. DNA Polymerase