At high altitudes, the atmospheric pressure is lower, so the oxygen partial pressure drops. The body responds by hyperventilating to increase oxygen intake. Hyperventilation leads to blowing off CO2, which lowers PCO2 and causes alkalosis. The low HCO3 is a compensatory metabolic acidosis, which is the body's attempt to bring pH back down. But since he's still in an alkalotic state, the primary problem is respiratory.
The options aren't given, but the correct answer should be respiratory alkalosis with partial metabolic compensation. The wrong options might include other acid-base disorders. For example, metabolic acidosis with respiratory compensation would have a low pH and high PCO2, which isn't the case here. Metabolic alkalosis would have high HCO3. So the key is the low PCO2 and pH over 7.45 indicating alkalosis.
**Core Concept**
This question tests understanding of high-altitude physiology and acid-base disorders. At extreme altitudes, reduced atmospheric pressure causes hypoxia, triggering hyperventilation to increase oxygen uptake. This leads to respiratory alkalosis, characterized by low PaCO₂ and elevated pH. The body partially compensates with metabolic acidosis (reduced HCO₃⁻), but pH remains alkalotic.
**Why the Correct Answer is Right**
The blood gas shows pH 7.55 (alkalotic), PaCO₂ 12 mmHg (↓, indicating hyperventilation), PaO₂ 30 mmHg (hypoxia), and HCO₃⁻ 20 mEq/L (↓, partial metabolic compensation). At 8,400m, ambient oxygen is ~30% of sea level, causing hypoxia. Hyperventilation reduces CO₂ (respiratory alkalosis). The kidneys excrete HCO₃⁻ over hours/days to partially counteract alkalosis. This is classic **acute high-altitude respiratory alkalosis with metabolic compensation**.
**Why Each Wrong Option is Incorrect**
**Option A:** *Metabolic acidosis* – Incorrect. pH is alkalotic (7.55), not acidotic. **Option B:** *Metabolic alkalosis* – Incorrect. HCO₃⁻ is low (20), not elevated. **Option C:** *Respiratory acidosis* – Incorrect. PaCO₂ is low (12), not high. **Option D:** *Mixed metabolic acidosis/alkalosis* – Incorrect. No evidence of conflicting acid-base processes; the compensation is orderly and consistent with altitude.
**Clinical Pearl / High-Yield Fact**
Remember the “altitude rule”: At high altitude, the primary acid-base disorder is **respiratory alkalosis** due to hyperventilation. The kidneys compensate by reducing HCO₃⁻, but pH remains alkalotic. Never assume metabolic acidosis in this context unless there’s additional pathology (e.g., lactic acidosis
Free Medical MCQs · NEET PG · USMLE · AIIMS
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