**Core Concept**
The question is testing the knowledge of a specific genetic disorder associated with the deletion of chromosome 11. This involves the understanding of cytogenetics, chromosomal abnormalities, and their clinical manifestations.

**Why the Correct Answer is Right**
The deletion of chromosome 11, particularly the part known as the DiGeorge syndrome or 22q11.2 deletion syndrome, leads to a condition characterized by thymic hypoplasia, parathyroid gland aplasia, and congenital heart defects. This is due to the disruption of the T-box transcription factor TBX1, which plays a crucial role in the development of these structures. The deletion also affects the expression of other genes involved in the development of the heart and the immune system.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because deletion of chromosome 11 does not lead to Cri-du-chat syndrome, which is typically associated with a deletion of part of chromosome 5.

**Option B:** This option is incorrect because deletion of chromosome 11 does not lead to Prader-Willi syndrome, which is typically associated with a deletion of part of chromosome 15.

**Option C:** This option is incorrect because deletion of chromosome 11 does not lead to Angelman syndrome, which is typically associated with a deletion of part of chromosome 15.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that chromosomal deletions can lead to various clinical manifestations depending on the specific genes involved. A detailed understanding of the affected genes and their functions is crucial for making an accurate diagnosis.

**Correct Answer:** D. DiGeorge syndrome.