**Core Concept**
Deletion of chromosome 11 is associated with a specific genetic disorder. This deletion affects various genes located on the long arm (q) of chromosome 11, leading to a condition characterized by developmental abnormalities and other systemic manifestations.
**Why the Correct Answer is Right**
The deletion of chromosome 11, particularly the region 11q23-qter, is associated with the development of Wilms tumor, anaplastic nephroblastoma. This is due to the loss of function of the WT1 gene, which plays a crucial role in the development and growth of the kidneys. The WT1 gene acts as a tumor suppressor, and its deletion leads to uncontrolled cell growth and tumor formation.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because deletion of chromosome 11 does not lead to Marfan syndrome, which is caused by mutations in the FBN1 gene on chromosome 15.
**Option B:** This option is incorrect because deletion of chromosome 11 does not lead to Turner syndrome, which is caused by the absence of one X chromosome, typically in females.
**Option C:** This option is incorrect because deletion of chromosome 11 does not lead to Prader-Willi syndrome, which is caused by the loss of function of genes located on the paternal copy of chromosome 15.
**Clinical Pearl / High-Yield Fact**
Wilms tumor is a type of cancer that primarily affects children, with a peak incidence between 2 and 4 years of age. Early recognition and treatment are crucial for improving outcomes in patients with this condition.
**Correct Answer:** D.
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