Degenerative changes in Huntington’s chorea are seen in
**Core Concept**
Huntington's chorea is a neurodegenerative disorder characterized by the progressive loss of neurons in the basal ganglia, particularly in the striatum. The degenerative changes in Huntington's chorea are primarily due to the expansion of a CAG repeat in the Huntingtin gene, leading to a toxic protein that causes neuronal damage and death.
**Why the Correct Answer is Right**
The correct answer is associated with the degenerative changes in the basal ganglia, particularly in the striatum. The striatum is a key structure involved in the pathophysiology of Huntington's chorea, and its degeneration leads to the characteristic motor symptoms of the disease. The expansion of the CAG repeat in the Huntingtin gene disrupts normal neuronal function, leading to the formation of toxic protein aggregates that cause neuronal damage and death.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because Huntington's chorea primarily affects the basal ganglia, not the cerebellum.
* **Option B:** This option is incorrect because Alzheimer's disease is primarily associated with degenerative changes in the hippocampus and temporal lobe, not the basal ganglia.
* **Option C:** This option is incorrect because Parkinson's disease is primarily associated with degenerative changes in the substantia nigra, not the basal ganglia.
**Clinical Pearl / High-Yield Fact**
A key feature of Huntington's chorea is the presence of choreiform movements, which are involuntary, dance-like movements that are characteristic of the disease. These movements are due to the degeneration of the striatum and the disruption of normal motor control.
**Correct Answer: C. Striatum.