Vitamin–B6 deficiency is seen with the use of all of the following drugs except :
## **Core Concept**
Vitamin B6 (pyridoxine) deficiency can be induced by certain medications. These drugs interfere with the metabolism or utilization of vitamin B6 in the body, leading to a deficiency state. The key to answering this question lies in understanding the mechanisms by which different drugs affect vitamin B6 levels.
## **Why the Correct Answer is Right**
The correct answer, , is a drug that does not typically induce vitamin B6 deficiency. To understand why, let's briefly review how some drugs affect vitamin B6 levels:
- **Isoniazid**, an antitubercular drug, forms a hydrazone with pyridoxal, which is then excreted, leading to increased urinary loss of vitamin B6.
- **Cycloserine** and **Penicillamine** can also interfere with vitamin B6 metabolism, though their mechanisms might be less direct.
## **Why Each Wrong Option is Incorrect**
- **Option A:** Isoniazid is known to cause vitamin B6 deficiency because it interferes with the metabolism of pyridoxine, making it a correct association with vitamin B6 deficiency.
- **Option B:** Cycloserine can also lead to vitamin B6 deficiency due to its interference with pyridoxine metabolism.
- **Option C:** Penicillamine can chelate pyridoxine, leading to deficiency.
## **Clinical Pearl / High-Yield Fact**
A key clinical point to remember is that patients on **Isoniazid** for tuberculosis treatment are often given **pyridoxine supplements** to prevent deficiency, which can manifest as peripheral neuropathy. This is a classic example of a drug-induced vitamin deficiency and its prevention.
## **Correct Answer:** .