All of the following drugs cause hemolysis in patients with G6PD deficiency except:
**Core Concept**
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that affects the enzyme responsible for maintaining the integrity of red blood cells by protecting them from oxidative stress. Patients with G6PD deficiency are prone to hemolysis when exposed to certain medications or substances that trigger oxidative stress.
**Why the Correct Answer is Right**
Drugs that cause hemolysis in patients with G6PD deficiency typically act by inducing oxidative stress, which depletes the reduced glutathione levels in red blood cells, leading to cell membrane damage and hemolysis. Examples of such drugs include antimalarials like primaquine, chloroquine, and sulfonamides like dapsone. These drugs are metabolized to form reactive oxygen species that overwhelm the antioxidant defenses of red blood cells in individuals with G6PD deficiency.
**Why Each Wrong Option is Incorrect**
**Option A:** Not provided.
**Option B:** Not provided.
**Option C:** Not provided.
**Option D:** Not provided.
**Clinical Pearl / High-Yield Fact**
A classic exam trap to remember is that "antimalarials" are a high-risk group for triggering hemolysis in patients with G6PD deficiency. This is particularly relevant for primaquine, which is commonly used to treat Plasmodium vivax malaria.
**Correct Answer:**
(To provide a complete answer, I need the options A, B, and C. Please provide them so I can complete the explanation.)