## **Core Concept**
G-6-PD (Glucose-6-phosphate dehydrogenase) deficiency is a genetic disorder that affects the enzyme glucose-6-phosphate dehydrogenase, leading to the vulnerability of red blood cells to oxidative stress. Certain drugs can trigger hemolysis in individuals with this deficiency by inducing oxidative stress.

## **Why the Correct Answer is Right**
is not provided in the query; however, we can infer that the correct answer is a drug that does not cause hemolysis in patients with G-6-PD deficiency. Typically, drugs that are safe in G-6-PD deficiency are those that do not generate significant oxidative stress.

## **Why Each Wrong Option is Incorrect**
- **Option A:** Certain drugs like **primaquine**, **dapsone**, and **quinidine** are known to cause hemolysis in G-6-PD deficient patients because they induce oxidative stress.
- **Option B:** Similarly, drugs such as **sulfonamides** (e.g., **sulfamethoxazole**) can also precipitate hemolysis due to their oxidative properties.
- **Option C:** **Nitrofurantoin**, an antibiotic, is another drug that can cause hemolysis in individuals with G-6-PD deficiency.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that patients with G-6-PD deficiency should avoid drugs known to induce hemolysis. A classic example of a drug to avoid is **primaquine**, which is used to treat malaria.

## **Correct Answer:** .