## **Core Concept**
G6PD (Glucose-6-phosphate dehydrogenase) deficiency is a genetic disorder that affects the enzyme responsible for maintaining the integrity of red blood cells by protecting them from oxidative damage. Certain drugs can trigger hemolysis (red blood cell destruction) in individuals with this deficiency by inducing oxidative stress.

## **Why the Correct Answer is Right**
The correct answer, , is a well-known drug that can precipitate hemolysis in G6PD-deficient individuals. This drug, like others in its class, can cause oxidative stress in red blood cells, leading to their premature destruction. The mechanism involves the generation of reactive oxygen species that the deficient enzyme cannot handle, resulting in cell lysis.

## **Why Each Wrong Option is Incorrect**
* **Option A:** is not commonly associated with drug-induced hemolysis in G6PD deficiency.
* **Option B:** is not typically known for causing hemolysis in G6PD-deficient patients.
* **Option C:** This option might seem plausible but is not the correct answer based on the context of G6PD deficiency and drug-induced hemolysis.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that certain drugs, including some antibiotics, antimalarials, and NSAIDs, can induce hemolysis in patients with G6PD deficiency. A classic example is , which is often tested in exams. Clinicians must always consider a patient's G6PD status before prescribing such medications to avoid this complication.

## **Correct Answer:** .