## **Core Concept**
G6PD (Glucose-6-phosphate dehydrogenase) deficiency is a genetic disorder that affects the enzyme responsible for maintaining the levels of NADPH in red blood cells. This enzyme deficiency makes red blood cells more susceptible to hemolysis under oxidative stress. Various drugs, infections, and certain foods can trigger hemolysis in individuals with G6PD deficiency.

## **Why the Correct Answer is Right**
The correct answer, **C. Chloramphenicol**, is not commonly associated with inducing hemolysis in G6PD deficiency. Chloramphenicol is an antibiotic that can cause bone marrow suppression as a side effect but is not typically known for causing hemolysis in G6PD-deficient patients. This makes it stand out as not causing hemolysis compared to the other options.

## **Why Each Wrong Option is Incorrect**
- **Option A:** Certain antimalarial drugs like primaquine are well-known to cause hemolysis in G6PD-deficient individuals. They induce oxidative stress, which red blood cells cannot handle due to the deficiency.
- **Option B:** Aspirin (acetylsalicylic acid) can cause hemolysis in G6PD-deficient patients, especially at higher doses, by inducing oxidative stress.
- **Option D:** Sulfonamides are another class of drugs that can precipitate hemolysis in individuals with G6PD deficiency by generating oxidative metabolites.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that not all drugs cause hemolysis in G6PD deficiency, and the risk varies with the specific drug and dose. Chloramphenicol, despite its potential for toxicity, is not commonly associated with drug-induced hemolysis in G6PD-deficient patients, making it a relatively safer option in this context.

## **Correct Answer:** C. Chloramphenicol