All of the following are true regarding G6PD deficiency except: March 2010
**Core Concept**
G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency is a genetic disorder affecting the enzyme responsible for maintaining the integrity of red blood cells. It leads to oxidative stress and hemolysis in individuals with this condition.
**Why the Correct Answer is Right**
G6PD deficiency is an X-linked recessive disorder, predominantly affecting males. This is because the gene encoding the G6PD enzyme is located on the X chromosome. The condition is characterized by the destruction of red blood cells (hemolysis) upon exposure to oxidative stressors such as certain medications, infections, or foods. The enzyme's primary function is to maintain the levels of NADPH in the pentose phosphate pathway, which in turn protects red blood cells from oxidative damage.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as G6PD deficiency indeed affects the red blood cells' ability to withstand oxidative stress, leading to hemolysis.
**Option B:** This option is incorrect as G6PD deficiency is indeed more common in males due to its X-linked recessive inheritance pattern.
**Option C:** This option is incorrect as G6PD deficiency does indeed have a genetic basis, with mutations in the G6PD gene leading to the enzyme's deficiency.
**Clinical Pearl / High-Yield Fact**
A classic exam trap in G6PD deficiency is the association of certain medications with hemolysis in affected individuals. The list of medications that can trigger hemolysis includes antimalarials (e.g., primaquine), certain antibiotics (e.g., sulfonamides), and anti-inflammatory agents (e.g., aspirin).
**Correct Answer: D.