Defect leading to thalassemia lies in –
Correct Answer: Haemoglobin
Description: Disorders off hemoglobin
Disorders of hemoglobin may be of two types -
1) Qualitative defect of hemoglobin (hemoglobinopathy)
Hem oglobinopathies are disorders of hemoglobin, characterized by a defect that results in abnormal structure of one of the globin chain of hemoglobin.
Examples are - Siclde cell anemia, HbC, HbE, HbD-Punjab, Hb O-Arab, Hb Lepore.
2) Quantitative defect of hemoglobin
These disorders are characterized by a defect that results in decreased rate of synthesis of one of the globin chain of hemoglobin.
Example - Thalassemia
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