All of the following proteins are decreased in Nephrotic syndrome. Except
**Core Concept**
Nephrotic syndrome is characterized by massive proteinuria, hypoalbuminemia, and edema. The renal damage leads to the loss of albumin and other proteins in the urine. The liver compensates for the loss of albumin by increasing its production, but the kidneys fail to properly reabsorb proteins back into the bloodstream.
**Why the Correct Answer is Right**
Proteins such as albumin, transferrin, and complement proteins are decreased in nephrotic syndrome due to excessive urinary loss. The liver attempts to compensate for the loss by increasing the production of these proteins, but the kidneys are unable to reabsorb them efficiently. This results in a decrease in serum levels of these proteins.
**Why Each Wrong Option is Incorrect**
**Option A:**
This protein is typically increased in nephrotic syndrome due to the liver's attempt to compensate for the loss of albumin.
**Option B:**
This protein is often decreased in nephrotic syndrome due to excessive urinary loss.
**Option C:**
This protein is typically decreased in nephrotic syndrome due to excessive urinary loss and impaired liver production.
**Clinical Pearl / High-Yield Fact**
In nephrotic syndrome, the liver compensates for the loss of albumin by increasing its production, but the kidneys fail to properly reabsorb proteins back into the bloodstream. This results in a decrease in serum levels of albumin and other proteins.
**Correct Answer:** A.