Dantrolene sodium reduces skeletal muscle tone by:

A. Reducing acetylcholine release from motor nerve endings

B. Suppressing spinal polysynaptic reflexes

C. Inhibiting the generation of muscle action potential

D. Reducing Ca2+ release from sarcoplasmic reticulum in the muscle fibre

Correct Answer: Reducing Ca2+ release from sarcoplasmic reticulum in the muscle fibre

Description: * Dantrolene is the drug of choice for the treatment of malignant hypehermia and neuroleptic malignant syndrome. * It acts as an antagonist of Ryanodine receptors (present on smooth endoplasmic reticulum). It inhibits the release of Ca2+ from sarcoplasmic reticulum in the muscle fibre.

Category: Pharmacology

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