Pharmacology Dantrolene sodium reduces skeletal muscle tone by: A Reducing acetylcholine release from motor nerve endings B Suppressing spinal polysynaptic reflexes C Inhibiting the generation of muscle action potential D Reducing Ca2+ release from sarcoplasmic reticulum in the muscle fibre 💡 Explanation Dantrolene sodium reduces skeletal muscle tone by: ✓ Correct Answer: D. Reducing Ca2+ release from sarcoplasmic reticulum in the muscle fibre