**Core Concept**
Congenital cytomegalovirus (CMV) infection is a leading cause of birth defects and developmental disabilities in children, and vertical transmission from mother to fetus can occur during pregnancy. Understanding the risk factors and modes of transmission is crucial for managing congenital CMV infection.

**Why the Correct Answer is Right**
The correct answer is related to the fact that primary CMV infection during pregnancy is associated with a higher risk of congenital CMV transmission compared to reactivation of latent CMV infection. This is because primary infection can lead to a higher viral load in the maternal bloodstream, increasing the likelihood of transmission to the fetus. The risk of congenital CMV transmission is also influenced by the timing of infection during pregnancy, with the highest risk occurring during the first trimester.

**Why Each Wrong Option is Incorrect**
* **Option A:** This statement is incorrect because while recurrent CMV infection can lead to high viral loads, it is not the primary concern in the context of congenital CMV transmission.
* **Option B:** This statement is incorrect because it does not specify the timing of infection during pregnancy, which is a critical factor in determining the risk of congenital CMV transmission.
* **Option D:** This statement is incorrect because it does not address the specific concern of the mother being pregnant again and is too vague.

**Clinical Pearl / High-Yield Fact**
It's essential to note that women who are pregnant or planning to become pregnant should be advised to avoid close contact with individuals who have CMV infection, such as those with immunocompromised conditions or children with CMV infection.

**Correct Answer:** C.