Cytogenetics for synovial cell sarcoma
Now, the options for the question are A to D, but they aren't listed here. However, the correct answer is supposed to be the cytogenetic abnormality associated with synovial sarcoma. Let me think about other sarcomas and their translocations to avoid confusion. For example, Ewing's sarcoma has t(11;22), and alveolar rhabdomyosarcoma has t(2;13) or t(1;13). These are different, so they can't be the correct answer here.
The user mentioned that the correct answer is not listed, but in a real exam setting, the options would include the t(X;18) translocation. So the correct answer would be an option stating that translocation. The other options would likely present other translocations associated with different sarcomas. For example, option A might be t(11;22), which is Ewing's. Option B could be t(12;21), which is seen in ALL. Option C might be t(9;22), the Philadelphia chromosome for CML. Option D would be the correct t(X;18) translocation.
Therefore, the key points here are the specific translocation for synovial sarcoma and distinguishing it from other sarcomas. The clinical pearl here is to remember that the t(X;18) is a hallmark of synovial sarcoma, and this translocation is diagnostic. Students should note that this is a high-yield fact for exams like NEET PG or USMLE.
**Core Concept**
Synovial sarcoma is characterized by a specific chromosomal translocation involving chromosomes X and 18. This translocation creates a fusion gene critical for tumor pathogenesis.
**Why the Correct Answer is Right**
The t(X;18)(p11;q11) translocation fuses the **SS18** gene on chromosome 18 with **SSX1** or **SSX2** on the X chromosome. This fusion protein disrupts normal cell cycle regulation and promotes oncogenesis. The translocation is diagnostic for synovial sarcoma and is absent in other sarcomas like Ewing sarcoma (t(11;22)) or alveolar rhabdomyosarcoma (t(2;13)).
**Why Each Wrong Option is Incorrect**
**Option A:** t(11;22)(q24;q12) is the hallmark of **Ewing sarcoma/primitive neuroectodermal tumor (PNET)**, involving the EWSR1-FLI1 fusion gene.
**Option B:** t(2;13)(