Cytochrome 450 is located in –
Correct Answer: Endoplasmic reticulum
Description: Ans. is 'c' i.e., Endoplasmic reticulumo The drug metabolizing enzymes are divided into two types :1. Microsomal# These are located on smooth endoplasmic reticulum primarily in liver, also in kidney, intestinal mucosa and lungs.# Examples are monooxygenase, cytochrome P450, glucronyl transferase.# They catalyze most of the oxidation, reduction, hydrolysis and glucuronide conjugation.# They are inducible by drugs, diet and other agencies.2. Non microsomal# These are present in the cytoplasm and mitochondria of hepatic cells as well as in other tissues including plasma.# Examples are flavoprotein oxidase, esterases, amidases and conjugases.# They catalyze some oxidation and reduction, many hydrolysis and all conjugation except glucuronidation.# They are not inducible but many show genetic polymorphism (acetyl transferase, pseudocholinesterase).
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now