**Core Concept**
Cyclosporine is an immunosuppressive medication widely used to prevent organ rejection in transplant patients and to treat autoimmune diseases. Its primary mechanism of action involves inhibiting calcineurin, which is a crucial enzyme in the activation of T-lymphocytes. Cyclosporine's pharmacological profile includes a range of adverse effects due to its impact on various physiological systems.

**Why the Correct Answer is Right**
Cyclosporine is known to cause hyperglycemia, not hypoglycemia, as a side effect. This is primarily due to its effect on pancreatic beta-cell function, leading to an increase in glucose production and release. Additionally, cyclosporine can induce insulin resistance, further contributing to hyperglycemia. This is a notable concern in patients with pre-existing diabetes or those at risk of developing glucose metabolism disorders.

**Why Each Wrong Option is Incorrect**
**Option A:** Hirsutism is indeed an adverse effect of cyclosporine, likely due to its androgenic properties and the subsequent increase in androgen levels.

**Option B:** Nephrotoxicity is a significant concern with cyclosporine, which can cause vasoconstriction of the renal arteries, leading to decreased renal blood flow and glomerular filtration rate.

**Option C:** Hypertension is also a recognized adverse effect of cyclosporine, which can be attributed to its vasoconstrictive properties and potential for fluid retention.

**Clinical Pearl / High-Yield Fact**
Cyclosporine's adverse effect profile highlights the importance of monitoring patients for signs of hyperglycemia, hypertension, and nephrotoxicity, particularly in the early stages of treatment. Regular laboratory assessments, including kidney function tests and blood glucose levels, are essential to mitigate these risks.

**✓ Correct Answer: D. Hypoglycemia. This is not a recognized adverse effect of cyclosporine.**