Cycle of microfilarea in mosquito –
**Core Concept**
The cycle of microfilariae in mosquitoes is a complex process involving the development of filarial parasites in the mosquito vector. This process is essential for the transmission of filariasis from the mosquito to humans. The mosquito acts as a biologic vector, allowing the parasite to undergo a series of developmental stages before being transmitted to a new host.
**Why the Correct Answer is Right**
The cycle of microfilariae in mosquitoes involves the following stages:
- The mosquito ingests microfilariae while feeding on the blood of an infected human.
- The microfilariae migrate to the mosquito's midgut, where they are phagocytosed by the cells lining the gut.
- The phagocytosed microfilariae then undergo a series of developmental stages, including molting and nuclear division, as they migrate through the mosquito's body.
- The third-stage larvae eventually reach the mosquito's salivary glands, where they mature into infective third-stage larvae.
- When the infected mosquito feeds on human blood, it regurgitates the infective larvae into the wound, allowing the parasite to infect a new host.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not relevant to the cycle of microfilariae in mosquitoes.
**Option B:** This option does not accurately describe the developmental stages of microfilariae in mosquitoes.
**Option C:** This option is incorrect as it does not describe the correct sequence of events in the mosquito's body.
**Clinical Pearl / High-Yield Fact**
The ability of mosquitoes to transmit filariasis is a prime example of the complex interactions between vectors, parasites, and hosts. Understanding the cycle of microfilariae in mosquitoes is crucial for developing effective control measures against filariasis.
**Correct Answer: C. The infective third-stage larvae are present in the mosquito's salivary glands.**