**Question:** Cushing's disease presents with -

A. Increased glucocorticoid production
B. Pressure neuropathy
C. Hypothyroidism
D. Hypercalcemia

**Core Concept:** Cushing's disease is a rare, chronic disorder characterized by excessive cortisol production due to a pituitary adenoma (macroadenoma) secreting adrenocorticotropic hormone (ACTH).

**Why the Correct Answer is Right:**
Cushing's disease leads to adrenal hyperplasia and increased production of cortisol, a glucocorticoid hormone. This excess cortisol causes a cascade of symptoms and signs, including hyperglycemia, hypertension, obesity, moon-shaped face, and muscle weakness.

**Why Each Wrong Option is Incorrect:**
A. Increased glucocorticoid production (correct)
B. Pressure neuropathy (incorrect; Cushing's disease does not cause peripheral nerve compression)
C. Hypothyroidism (incorrect; Cushing's disease does not cause primary hypothyroidism)
D. Hypercalcemia (incorrect; Cushing's disease does not typically cause hypercalcemia unless there is secondary involvement)

**Clinical Pearl:**
Cushing's disease is important to recognize as it can be life-threatening if left untreated. The diagnosis is based on clinical findings, biochemical tests, and imaging studies. Treatment includes surgery, radiation therapy, and medications like ketoconazole or mitotane in case of inoperable tumors.

**Correct Answer:** A. Increased glucocorticoid production