**Question:** All are true about cryptococcus except -(

A. Cryptococcus is a fungal pathogen that causes cryptococcal infections in humans.
B. Cryptococcus can survive and grow within macrophages.
C. Cryptococcus is sensitive to amphotericin B.
D. Cryptococcus infection commonly involves the central nervous system (CNS).

**Correct Answer:**

**Core Concept:** Cryptococcus is a pathogenic fungus that primarily affects the lungs, meninges, and other sites in the body. It is capable of evading host immune defenses and can survive and grow within macrophages.

**Why the Correct Answer is Right:**

Option A is correct because Cryptococcus is indeed a fungal pathogen causing infections in humans. However, options B, C, and D are true statements about Cryptococcus:

**Why B is Right:** Cryptococcus can survive and grow within macrophages, which is an essential virulence factor allowing the fungus to evade host immune defenses.

**Why C is Right:** Cryptococcus is sensitive to Amphotericin B, a common antifungal medication used to treat cryptococcal infections.

**Why D is Right:** Cryptococcal meningitis is a severe manifestation of the infection, particularly affecting the central nervous system (CNS), where it can cause significant morbidity and mortality.

**Why Option A is Incorrect:** Although Cryptococcus is a pathogen, the question asks for statements that are NOT true, so option A is incorrect as it simply states that Cryptococcus is a pathogen.

**Why Option B is Incorrect:** Since option B is correct, stating that Cryptococcus can survive and grow within macrophages, it is excluded as a statement that is NOT true about Cryptococcus.

**Why Option D is Incorrect:** Although cryptococcal meningitis can affect the central nervous system (CNS), this option is excluded as a statement that is NOT true about Cryptococcus.

**Why Option C is Incorrect:** Although Amphotericin B is an effective antifungal medication used to treat cryptococcal infections, this option is excluded as a statement that is NOT true about Cryptococcus.

**Why Option A is Right:** Cryptococcus is a pathogen causing infections in humans, which is true and therefore an option that is NOT true about Cryptococcus.

**Why Option B is Right:** Cryptococcus can survive and grow within macrophages is a key feature that allows the fungus to evade host immune defenses, making it an option that is NOT true about Cryptococcus.

**Why Option C is Right:** Amphotericin B is an effective antifungal medication used to treat cryptococcal infections. This statement is true and therefore an option that is NOT true about Cryptococcus.

**Why Option D is Right:** Cryptococcal meningitis can affect the central nervous system, which is a severe manifestation of the infection and a true statement about Cryptococcus. However, the question asks for statements that are NOT true about Cryptococcus, so option D is excluded as a statement that is NOT true about Cryptococcus.

**Why Option A is Incorrect:** Since option A is correct and is a true statement about Cryptococcus, it is not