**Question:** CRP can be detected by

A. Latex agglutination
B. Enzyme linked immunosorbent assay (ELISA)
C. Latex agglutination and ELISA
D. Latex agglutination and turbidimetry

**Correct Answer:** D. Latex agglutination and turbidimetry

**Core Concept:** C-reactive protein (CRP) is a laboratory test used to assess inflammation and infection in the body. CRP is a plasma protein that increases significantly in response to acute phase reactants triggered by inflammation or infection.

**Why the Correct Answer is Right:** CRP can be detected using two main methods: latex agglutination and turbidimetry.

**Why Each Wrong Option is Incorrect:**

A. Latex agglutination is a test that involves the interaction between positively charged CRP molecules and negatively charged latex particles. While this test is useful, it is not exclusive to latex agglutination, as turbidimetry is also used for CRP detection.

B. ELISA is an assay used for detecting specific antibodies, antigens, or cytokines, not CRP. ELISA is not a method for measuring CRP levels directly.

C. Latex agglutination is used for detecting CRP, but ELISA is also used for detecting specific antibodies, antigens, or cytokines, making this option incorrect as well.

**Clinical Pearl / High-Yield Fact:** Latex agglutination and turbidimetry are the two main methods for CRP detection. These tests measure the change in light transmission or turbidity as CRP molecules bind to specific antibodies or latex particles, respectively. CRP elevation indicates acute inflammation or infection, prompting further diagnostic workup and management adjustments.