All of the following are true regarding sodium cromoglycate except: March 2010
**Core Concept**
Sodium cromoglycate is a mast cell stabilizer used in the management of allergic conditions such as asthma and allergic conjunctivitis. It works by preventing the release of histamine and other mediators from mast cells, thereby reducing inflammation and symptoms.
**Why the Correct Answer is Right**
Sodium cromoglycate acts by stabilizing the mast cell membrane, thereby preventing the release of histamine and other chemical mediators. This is achieved by inhibiting the calcium ion influx into the mast cell, which is essential for the degranulation process. The drug does not have any significant effect on histamine release once the mast cell has been activated.
**Why Each Wrong Option is Incorrect**
**Option A:** Sodium cromoglycate is a mast cell stabilizer, and it is indeed used in the management of allergic conditions. This statement is true.
**Option B:** Sodium cromoglycate does not have any significant effect on histamine release once the mast cell has been activated. This statement is true.
**Option C:** This option is blank, so we will move on to the next one.
**Clinical Pearl / High-Yield Fact**
Sodium cromoglycate is often used as an alternative to corticosteroids in the management of allergic conditions, as it has a more favorable side effect profile. It is also used in children and pregnant women, as it is generally considered safe.
**Correct Answer: D.**