True about Creutzfeldt-Jacob’s disease is -a) Inheritable diseaseb) Corneal implants can transmit diseasec) Caused by DNA containing organismd) Arthropod borne disease
First, the core concept. CJD is a prion disease, right? Prions are infectious agents made of protein without nucleic acids. So the key points here are that it's caused by prions, which are proteinaceous, not DNA or RNA viruses. Also, transmission routes like corneal transplants are possible because prions are resistant to standard sterilization.
Now, the correct answer is option B: Corneal implants can transmit the disease. I need to explain why. Prions are present in the brain and other tissues, including the cornea. Since prions are resistant to heat and chemicals, they can survive in tissues used for transplants unless properly decontaminated. So, corneal transplants from an infected donor can transmit CJD.
For the incorrect options: Option A says it's inheritable. There's a variant called familial CJD, but the most common form is sporadic. So while some cases are inherited, the question is about the true statement. So A is not universally correct. Option C claims it's caused by a DNA organism. But prions don't have DNA or RNA. Option D mentions arthropod-borne, which is unrelated; CJD isn't spread by insects.
Clinical pearl: Remember that prions are protein-based and resistant to standard sterilization methods. High-yield fact for exams is that CJD is transmissible via corneal transplants and that prions lack nucleic acids.
I need to structure this into the required sections, making sure each part is concise and fits within the character limit. Also, avoid markdown except for bold and bullet points. Check for any medical inaccuracies, like confirming the transmission routes and the nature of prions. Make sure the explanation is clear for a postgraduate student.
**Core Concept**
Creutzfeldt-Jakob disease (CJD) is a transmissible, rapidly progressive neurodegenerative disorder caused by prions—misfolded proteins that induce abnormal folding of normal prion protein (PrP^C). It is distinct from conventional pathogens as prions lack nucleic acids like DNA or RNA.
**Why the Correct Answer is Right**
**Option B** is correct because CJD can be transmitted via corneal implants. Prions are present in the central nervous system and peripheral tissues, including the cornea. These proteins are highly resistant to standard sterilization methods (e.g., heat, formalin), allowing transmission through corneal grafts, dura mater transplants, or contaminated surgical instruments. This underscores the importance of tissue screening and specialized decontamination protocols.
**Why Each Wrong Option is Incorrect**
**Option A:** While familial CJD exists (autosomal dominant mutations in the PRNP gene), most cases are sporadic (not inheritable). The question asks for a "true" statement, and sporadic CJD is more common.
**Option C:** CJD is caused by prions, which are misfolded proteins **without** DNA or RNA. This distinguishes prion diseases from viral or bacterial infections.
**Option D:**