Creola bodies are seen in
**Question:** Creola bodies are seen in
A. Hepatitis
B. Malaria
C. Typhoid fever
D. Chronic active hepatitis
**Core Concept:** Creola bodies are intracytoplasmic inclusions found in the hepatocytes of patients with chronic hepatitis, particularly chronic active hepatitis. They are composed of viral proteins and are associated with hepatitis B virus infection.
**Why the Correct Answer is Right:** Creola bodies are specific to chronic active hepatitis caused by hepatitis B virus (HBV). They are formed due to the accumulation of viral proteins within the hepatocytes, leading to their characteristic appearance in histological sections. The correct answer, D, represents chronic active hepatitis, which is associated with the presence of Creola bodies.
**Why Each Wrong Option is Incorrect:**
A (Hepatitis): Hepatitis can be caused by various pathogens, including hepatitis A, B, C, D, and E viruses. However, Creola bodies are specific to hepatitis B and not seen in hepatitis A, C, D, or E infections.
B (Malaria): Creola bodies are not associated with malaria, which is caused by Plasmodium parasites. Malaria-induced intracytoplasmic inclusions are known as Heinz bodies.
C (Typhoid fever): Typhoid fever is caused by Salmonella typhi and is characterized by Salmonellosis-induced histopathological changes, not Creola bodies.
**Clinical Pearl:** The presence of Creola bodies in a liver biopsy specimen, particularly in combination with other histopathological markers of chronic active hepatitis, can help in diagnosing hepatitis B infection.
**Correct Answer:** D (Chronic active hepatitis)