Corpus luteum in the first 6 weeks of pregnancy is maintained by –
First, the corpus luteum is formed after ovulation. Normally, if there's no pregnancy, it regresses after about 14 days. But during pregnancy, it's maintained longer. The key here is the hormone that sustains the corpus luteum beyond its usual lifespan.
In early pregnancy, the developing embryo starts producing human chorionic gonadotropin (hCG). hCG is structurally similar to luteinizing hormone (LH), so it acts on the same receptors in the corpus luteum. This stimulation keeps the corpus luteum functional, allowing it to continue producing progesterone, which is crucial for maintaining the uterine lining and supporting the pregnancy until the placenta takes over around the 10th week.
Now, the options might include LH, estrogen, progesterone, or maybe follicle-stimulating hormone (FSH). Let's think. The correct answer is hCG. So if the options are A to D, and one of them is hCG, then that's the right choice. The other options: LH is involved in ovulation but not in maintaining the corpus luteum in pregnancy. Estrogen and progesterone are produced by the corpus luteum, so they aren't the ones maintaining it. FSH is more involved in follicular development, not the luteal phase.
Wait, but maybe there's a trick. Like, in some contexts, LH might be a distractor. But in early pregnancy, the hCG from the placenta takes over the role of LH in sustaining the corpus luteum. So the correct answer should definitely be hCG. The other options don't fit. The clinical pearl here is that hCG is the key hormone in early pregnancy that sustains the corpus luteum, which is why hCG is detected in pregnancy tests. Also, the transition from corpus luteum to placental progesterone production happens around week 10. So students should remember that hCG is crucial in the first trimester for luteal support.
**Core Concept**
The corpus luteum is a temporary endocrine structure that secretes progesterone to maintain the endometrium. In early pregnancy, its survival depends on **human chorionic gonadotropin (hCG)**, which mimics luteinizing hormone (LH) and prevents luteolysis.
**Why the Correct Answer is Right**
During pregnancy, the developing embryo produces **hCG**, a glycoprotein hormone structurally similar to LH. hCG binds to LH receptors on the corpus luteum, stimulating it to continue secreting progesterone and estrogen. This prevents endometrial shedding and supports the pregnancy until the placenta can take over hormone production (~10β12 weeks).
**Why Each Wrong Option is Incorrect**
**Option A:** *Luteinizing hormone (LH)* is critical for ovulation but declines after ovulation. It does not sustain the corpus luteum in pregnancy.
**Option B:** *Estrogen* is produced by the corpus luteum itself