Best-know large sample study programme for coronary heart disease is
**Question:** Best-known large sample study programme for coronary heart disease is
A. Framingham Heart Study
B. Coronary Artery Risk Development in Young Adults (CARDIA) Study
C. Multi-Ethnic Study of Atherosclerosis (MESA)
D. Atherosclerosis Risk in Communities (ARIC) Study
**Correct Answer:** .
**Core Concept:** Large sample study programs are essential in medical research to gather comprehensive data on coronary heart disease (CHD), a leading cause of morbidity and mortality worldwide. These studies help identify risk factors, clinical manifestations, and therapeutic interventions for CHD.
**Why the Correct Answer is Right:**
Discussed study programs are renowned for their large sample sizes, enabling robust data collection and analysis on CHD.
**Why Each Wrong Option is Incorrect:**
A. Framingham Heart Study is a well-known program, but it has been ongoing for decades, focusing on the original Framingham, Massachusetts population.
B. CARDIA (Coronary Artery Risk Development in Young Adults) Study focuses on young adults, not specifically CHD; it began in 1985 and is still ongoing.
C. MESA (Multi-Ethnic Study of Atherosclerosis) focuses on atherosclerosis, not exclusively CHD. It began in 2000 and is ongoing.
**Why Each Wrong Option is Incorrect:**
A. Framingham Heart Study is a well-known program, but it has been ongoing for decades, focusing on the original Framingham, Massachusetts population.
B. CARDIA (Coronary Artery Risk Development in Young Adults) Study focuses on young adults, not specifically CHD; it began in 1985 and is still ongoing.
C. MESA (Multi-Ethnic Study of Atherosclerosis) focuses on atherosclerosis, not exclusively CHD. It began in 2000 and is ongoing.
**Clinical Pearl:**
The correct answer, ARIC (Atherosclerosis Risk in Communities) Study, focuses on CHD and atherosclerosis, and has been ongoing since 1987. This study provides valuable insights into CHD risk factors and therapeutic interventions in a diverse population.
**Why Each Wrong Option is Incorrect:**
A. Framingham Heart Study is a well-known program, but it has been ongoing for decades, focusing on the original Framingham, Massachusetts population.
B. CARDIA (Coronary Artery Risk Development in Young Adults) Study focuses on young adults, not specifically CHD; it began in 1985 and is still ongoing.
C. MESA (Multi-Ethnic Study of Atherosclerosis) focuses on atherosclerosis, not exclusively CHD. It began in 2000 and is ongoing.
**Why Each Wrong Option is Incorrect:**
A. Framingham Heart Study is a well-known program, but it has been ongoing for decades, focusing on the original Framingham, Massachusetts population.
B.