**Question:** Coomb's + ve Hemolytic Anaemia is seen in all except-

A. Autoimmune Hemolytic Anaemia
B. DIC (Disseminated Intravascular Coagulation)
C. Hemolytic Anaemia due to drug-induced damage
D. Hemolytic Anaemia due to infection

**Correct Answer:** .

**Core Concept:**
Coomb's test is a diagnostic test used to identify the presence of antibodies against red blood cells (RBCs) in a patient's serum. Coombs' +ve Hemolytic Anaemia is a type of autoimmune Hemolytic Anaemia where antibodies against RBCs are present.

**Why the Correct Answer is Right:**
Coomb's test is positive in certain clinical scenarios, primarily autoimmune Hemolytic Anaemia. In this case, the antibodies in the patient's serum bind to the RBCs, causing them to stick together and get destroyed in the spleen.

**Why Each Wrong Option is Incorrect:**

A. Autoimmune Hemolytic Anaemia: This is the correct answer and the condition being targeted by the question. Autoimmune Hemolytic Anaemia is characterized by the presence of antibodies against RBCs, leading to destruction of RBCs.

B. Disseminated Intravascular Coagulation (DIC): DIC is a coagulation disorder characterized by excessive activation of coagulation cascade, leading to widespread clot formation and organ damage. It is not related to RBC destruction and Coomb's test positivity.

C. Hemolytic Anaemia due to drug-induced damage: This condition is caused by drugs that directly damage RBCs, leading to their destruction. Coomb's test is not typically positive in this scenario.

D. Hemolytic Anaemia due to infection: Infections can cause hemolysis via various mechanisms, but the question specifically mentions Coomb's test positivity. Hemolytic Anaemia due to infections may or may not involve Coomb's test positivity, making this option incorrect.

**Clinical Pearl:**

In clinical practice, Coombs' test positivity can be seen in autoimmune Hemolytic Anaemia, where the antibodies in the patient's serum cause RBCs to stick together and get destroyed in the spleen. In contrast, the wrong options involve various causes of hemolysis, including drug-induced damage, infection, and disseminated intravascular coagulation (DIC), but none of these conditions are associated with Coombs' test positivity.