**Core Concept**
Glaucoma is a group of eye conditions that damage the optic nerve, often due to abnormally high pressure in the eye. Managing intraocular pressure (IOP) is a crucial aspect of glaucoma treatment. Certain medications can either increase or decrease IOP, making them contraindicated in glaucoma.

**Why the Correct Answer is Right**
The correct answer is a medication that increases IOP, which would exacerbate glaucoma. This medication stimulates the alpha-2 adrenergic receptors in the eye, leading to increased aqueous humor production and decreased outflow, thereby increasing IOP.

**Why Each Wrong Option is Incorrect**
* **Option A:** This medication is actually used to decrease IOP by increasing outflow through the uveoscleral pathway. It is a prostaglandin analog, which is commonly used in glaucoma treatment.
* **Option B:** This medication is a carbonic anhydrase inhibitor, which decreases IOP by reducing aqueous humor production. It is also used in glaucoma treatment.
* **Option C:** This medication is a beta-blocker, which decreases IOP by reducing aqueous humor production and increasing outflow. It is another commonly used medication in glaucoma treatment.

**Clinical Pearl / High-Yield Fact**
When managing glaucoma, it's essential to remember that medications that increase IOP should be avoided. A mnemonic to keep in mind is "PAIN," which stands for "Prostaglandins, Alpha-2 agonists, and IOP-increasing medications" that should be avoided in glaucoma.

**Correct Answer:** C. Epinephrine