All of the following drugs are contraindicated in patients with G-6-PD deficiency, except
**Core Concept**
Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is a genetic disorder that affects the enzyme responsible for protecting red blood cells from oxidative damage. Individuals with this deficiency are prone to hemolysis when exposed to certain medications, which can trigger oxidative stress.
**Why the Correct Answer is Right**
The correct answer is **Primaquine**. Primaquine is an antimalarial medication that is metabolized to reactive intermediates, which can cause oxidative stress and lead to hemolysis in individuals with G-6-PD deficiency. This is because primaquine generates reactive oxygen species (ROS) through the oxidation of NADPH, which is depleted in G-6-PD deficient red blood cells.
**Why Each Wrong Option is Incorrect**
**Option A:** **Sulfinpyrazone** is a uricosuric agent that can induce hemolysis in G-6-PD deficient individuals due to its oxidative properties. It is not the correct answer because it is contraindicated in patients with G-6-PD deficiency.
**Option B:** **Chloroquine** is also an antimalarial medication that can cause hemolysis in G-6-PD deficient individuals. However, it is not the correct answer because it is generally considered safe in low doses.
**Option C:** **Naproxen** is a nonsteroidal anti-inflammatory drug (NSAID) that can induce hemolysis in G-6-PD deficient individuals. It is not the correct answer because it is contraindicated in patients with G-6-PD deficiency.
**Clinical Pearl / High-Yield Fact**
When prescribing medications to patients with G-6-PD deficiency, it is essential to consider the potential for hemolysis and choose alternative medications that are safe and effective.
**Correct Answer:** C. Naproxen.