True about Dupuytren’s contracture -a) A/w peyronie’s diseaseb) First affect index fingerc) Nodule formation & thickening of palmar fasciad) Amputation may be required

**Core Concept**
Dupuytren's contracture is a **fibrotic disorder** characterized by the thickening of the **palmar fascia**, leading to flexion contracture of the fingers. It is often associated with other conditions. The underlying principle involves the **pathological deposition of collagen**.

**Why the Correct Answer is Right**
The correct answer involves the association with **Peyronie's disease**, which is also a fibrotic condition, and the characteristic **nodular formation and thickening of the palmar fascia**. Dupuytren's contracture typically starts in the **ring or little finger**, not the index finger.

**Why Each Wrong Option is Incorrect**
**Option B:** is incorrect because the index finger is not typically the first to be affected. **Option D:** is incorrect as amputation is rarely required.

**Clinical Pearl / High-Yield Fact**
A key point to remember is the association between Dupuytren's contracture and other fibrotic diseases, as well as its characteristic clinical presentation.

**Correct Answer:** C. Nodule formation & thickening of palmar fascia, a/w peyronie's disease

✓ Correct Answer: C. acd