**Core Concept**
Dupuytren's contracture is a fibroproliferative disorder characterized by the abnormal formation of collagen and fibroblasts in the palmar fascia, leading to flexion contracture of the fingers. This condition is often associated with genetic predisposition, trauma, and aging.

**Why the Correct Answer is Right**
The condition typically affects the palmar fascia of the hand, particularly the fourth and fifth fingers, where the fascia is thicker and more prone to fibrosis. The abnormal proliferation of fibroblasts and deposition of collagen lead to the formation of nodules and cords that eventually contract, causing flexion deformity of the fingers. The exact mechanism is not fully understood, but it is thought to involve an imbalance between collagen synthesis and degradation.

**Why Each Wrong Option is Incorrect**
**Option A:** Dupuytren's contracture can affect any finger, but it is most commonly seen in the fourth and fifth fingers. It is less common in the thumb and index finger.
**Option B:** While Dupuytren's contracture is associated with genetic predisposition, it is not exclusively a familial condition. Environmental factors such as trauma and aging also play a role.
**Option C:** Dupuytren's contracture is not typically associated with inflammation or infection. It is a fibroproliferative disorder, not an infectious or inflammatory condition.

**Clinical Pearl / High-Yield Fact**
Dupuytren's contracture is a common condition in older adults, particularly those of European descent. It is often seen in patients with a family history of the condition, and it may be associated with other fibroproliferative disorders, such as Peyronie's disease and plantar fibromatosis.

**Correct Answer:** D.