Molluscum contagiosum is caused by: March 2013
Molluscum contagiosum is definitely caused by a poxvirus. The specific name is Molluscum contagiosum virus (MCV). It's part of the Poxviridae family. Other poxviruses include variola (smallpox) and vaccinia. Now, why isn't it another virus like HPV or herpes? Because those cause different conditions. HPV causes warts and some cancers, while herpes simplex causes cold sores and genital herpes. The key here is the family and the specific virus.
The core concept here is the classification of the virus causing molluscum. The correct answer should be Molluscum contagiosum virus. The other options might be other viruses like HPV, HSV, or even bacterial agents, but they're incorrect. For example, if an option says "Herpes simplex virus," that's wrong because it causes a different type of skin lesion. Similarly, HPV types 6 and 11 cause genital warts, not molluscum.
Clinical pearls: Molluscum is a viral skin infection with characteristic umbilicated papules. It's self-limiting but can persist. Treatments include cryotherapy or topical agents, but the virus itself is the key for the exam question. Students should remember that it's a poxvirus, not a herpesvirus or papillomavirus. The exam might trick you by listing similar-sounding viruses, so knowing the correct family and name is crucial.
**Core Concept**
Molluscum contagiosum is a viral skin infection caused by the **Molluscum contagiosum virus (MCV)**, a member of the **Poxviridae** family. It presents as umbilicated papules and is distinct from warts (HPV) or herpes lesions (HSV).
**Why the Correct Answer is Right**
MCV is a **double-stranded DNA virus** in the Poxviridae family, specifically the *Molliviridae* subfamily. It infects the epidermis, leading to characteristic skin lesions. The virus replicates in the stratum corneum, forming a central core of viral material (the "umbilication") and a surrounding collar of keratin. Unlike other poxviruses (e.g., variola), MCV is self-limiting and non-lethal.
**Why Each Wrong Option is Incorrect**
**Option A:** *Herpes simplex virus (HSV)* causes cold sores or genital ulcers, not umbilicated papules.
**Option B:** *Human papillomavirus (HPV)* causes warts (e.g., common or plantar warts), which lack the central umbilication seen in molluscum.
**Option C:** *Varicella-zoster virus (VZV)* causes chickenpox and shingles, characterized by fluid-filled vesicles, not