**Core Concept:** Thumb sucking is a normal behavior in infants and young children, which is typically discontinued as the child grows and teeth develop. When thumb sucking persists into the permanent dentition phase, it can lead to malocclusion (bad bite) and dental arch constriction.

**Why the Correct Answer is Right:** Dr. Edward Angle, a renowned orthodontist, introduced the "Invisalign" appliance to correct malocclusion resulting from thumb sucking. The Invisalign appliance is a series of transparent aligners that gradually move teeth into the correct position.

**Why Each Wrong Option is Incorrect:**

A. Dr. Charles Tweed is known for his contributions to orthodontics, but he introduced the Twin Block appliance for Class II malocclusion, not specifically for thumb sucking-induced malocclusion.

B. Dr. Edward H. Angle developed the Angle Classification system for classifying malocclusions, but not a specific appliance for thumb sucking-induced malocclusion.

C. Dr. Edward J. Deinzer is known for his work on orthodontic forces, but he didn't introduce an appliance for thumb sucking-induced malocclusion.

D. Dr. Edward H. Angle introduced the Invisalign appliance to correct malocclusion resulting from thumb sucking.

**Clinical Pearl:** Early identification and intervention for thumb sucking-induced malocclusion are crucial to prevent further complications and ensure proper dental arch development in growing children. Invisalign is a modern and aesthetically pleasing option for treating these cases, as opposed to traditional fixed appliances, which may be more noticeable and affect the child's self-esteem.