The role of plasmids in conjugation was first described by Lederberg and Tatum(46) in ?
**Core Concept:**
Conjugation is a mode of bacterial reproduction that allows the exchange of genetic material between bacteria. Plasmids are extrachromosomal circular DNA molecules that can carry genes encoding for resistance to antibiotics, enzymes, etc. In this process, plasmids are transmitted from one bacterium to another through direct cell-cell contact.
**Why the Correct Answer is Right:**
The correct answer refers to the year when the concept of conjugation involving plasmids was first described by Lederberg and Tatum. In 1952, they demonstrated that plasmids could be horizontally transmitted between bacteria, thereby explaining the genetic variation observed in bacterial populations.
**Why Each Wrong Option is Incorrect:**
A. This option is incorrect because Lederberg and Tatum published their work in 1952, making it the correct year.
B. This option is incorrect as Lederberg and Tatum are the ones who described the concept.
C. Although this person is mentioned in the question, they are not the correct answer. Lederberg and Tatum were the ones who first described conjugation involving plasmids.
D. This option is incorrect as Lederberg and Tatum are the ones who published the findings, not George.
**Why the Correct Answer is Right:**
The correct answer "1952" refers to the year when Lederberg and Tatum first described the role of plasmids in conjugation. Their seminal work demonstrated the existence of plasmids and their role in transmitting genetic material between bacteria, shedding light on the genetic variation observed in bacterial populations.
**Why Each Wrong Option is Incorrect:**
A. This option is incorrect because 1952 is the correct year when the concept was first described, not George's birth year.
B. George Elkind is not relevant to the correct answer, as it is the year 1952 that holds significance for the discovery of plasmid in conjugation.
C. This option is incorrect as it mentions George Elkind, not the person responsible for describing the concept, which is Lederberg and Tatum.
D. This option is incorrect as the correct answer is the year 1952, not George's last name.
**Clinical Pearl:**
In bacteriology, conjugation is a crucial process that contributes to antibiotic resistance in bacteria. The discovery of plasmids and their role in conjugation by Lederberg and Tatum in 1952 is a foundational event in understanding bacterial genetics and antibiotic resistance.