## **Core Concept**
Congenital toxoplasmosis occurs when a pregnant woman acquires a primary infection with *Toxoplasma gondii*, leading to transmission of the parasite to the fetus. This condition can result in severe consequences for the newborn, including neurological damage and ocular abnormalities.

## **Why the Correct Answer is Right**
The correct answer is related to the understanding that congenital toxoplasmosis typically occurs when a woman has a primary infection during pregnancy. The parasite can cross the placenta and infect the fetus, leading to congenital toxoplasmosis. The statement that is false regarding congenital toxoplasmosis needs to be identified among the provided options.

## **Why Each Wrong Option is Incorrect**
- **Option A:** Typically, congenital toxoplasmosis is associated with primary maternal infection rather than reactivation of latent infection. Reactivation can occur in immunocompromised individuals but is less commonly associated with congenital transmission.
- **Option B:**
- **Option C:**
- **Option D:** Without specific details on each option, we focus on general knowledge: Congenital toxoplasmosis is a significant concern during primary maternal infection, especially in the first and early second trimester.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that **maternal infection during the first trimester** has a lower transmission rate to the fetus (about 10-15%) but results in more severe outcomes, whereas **infection in the third trimester** has a higher transmission rate but often results in milder or asymptomatic disease at birth.

## **Correct Answer:** D. Toxoplasmosis is usually symptomatic at birth.
**Correct Answer: D. Toxoplasmosis is usually symptomatic at birth.**