Congenital lactic acidosis occur due to the deficiency of which of the following enzyme?
Correct Answer: Pyruvate dehydrogenase enzyme complex
Description: Inherited pyruvate dehydrogenase deficiency, presents with lactic acidosis. Due to lack of pyruvate dehydrogenase,there will be lack of Acetyl co A production and pyruvate to lactate conversion occurs leading to accumulation of lactic acid Causes of lactic acidosis: 1. Tissue hypoxia 2. Mitochondrial disorders 3. Deficiency of: PDH Enzyme TCA cycle enzymes Vit B1 4. Poisoning : Cyanide, Mercury, Arsenite Reference: Harper's Illustrated Biochemistry 30th Edition Page no: 174
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Biochemistry
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