Effects of SLE on pregnancy : Risks of lupus rash,anemia, leukopenia, thromboctopenia and renal failure are increased. They are increased risks of First trimester miscarriage,lupus nephritis, reccurent DVT,PIH, Prematurity,IUGR and stillbihs. Neonatal lupus syndrome is due to crossing of maternal lupus antibodies(anti-RO or anti-La) to the fetus causing Hemolytic anemia,leukemia and thrombocytopenia. Isolated congenital hea block is pesent in about one-third of cases. Effect of Diabetes on pregnancy: Congenital Malformation (6-10%) is related to the severity of diabetes affeting organogenesis, in the firs trimester(both type 1 and tye 2) Effects of Congenital hea disease of mother on Pregnancy Likely to cause hea disease in newborn accounts for 3-13% Reference DC.Duttas textook of OBG ,9th edition